Adapalene + Clindamycin is a combination of two medicines: Adapalene and Clindamycin, which treats pimples (acne). Adapalene is a form of vitamin A which prevents accumulation of the sebum (skin’s natural oil), unblocks the pores and allows natural exfoliation of the outer layers of skin. Clindamycin is an antibiotic which works by penetrating into the skin and killing acne-causing bacteria.